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Thus, CF is considered an autosomal recessive disease.The CFTR gene, found at the q31.2 locus of chromosome 7, is 230,000 base pairs long, and creates a protein that is 1,480 amino acids long.

Malabsorption leads to malnutrition and poor growth and development because of calorie loss.Because factors II, VII, IX, and X (clotting factors) are vitamin K–dependent, low levels of vitamin K can result in coagulation problems.Consequently, when a child presents with unexplained bruising, a coagulation evaluation may be warranted to determine whether an underlying disease is present.The liver fails to rid the blood of toxins and does not make important proteins, such as those responsible for blood clotting.The pancreas contains the islets of Langerhans, which are responsible for making insulin, a hormone that helps regulate blood glucose.

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